10.1371/journal.pone.0072229.g005
Paige A. Winkler
Paige
A. Winkler
Kari J. Ekenstedt
Kari
J. Ekenstedt
Laurence M. Occelli
Laurence
M. Occelli
Anton V. Frattaroli
Anton
V. Frattaroli
Joshua T. Bartoe
Joshua
T. Bartoe
Patrick J. Venta
Patrick
J. Venta
Simon M. Petersen-Jones
Simon
M. Petersen-Jones
Immunohistochemistry on frozen retinal sections from age (8 wk) and sex matched (female) control and affected dogs.
Public Library of Science
2013
genetics
Model organisms
Animal models
neuroscience
Sensory systems
Visual system
systems biology
ophthalmology
Inherited eye disorders
Retinal disorders
Veterinary diseases
retinal
sections
matched
affected
2013-08-19 02:31:19
Figure
https://plos.figshare.com/articles/figure/_Immunohistochemistry_on_frozen_retinal_sections_from_age_8_wk_and_sex_matched_female_control_and_affected_dogs_/775810
<p>Images on the left are from the control dog and images on the right are from the affected dog. Panels A and B are stained with GARP-CNGB1 N-terminal antibody (green) and DAPI (blue). GARP proteins are present in both the control and affected samples. Panels C and D were stained with CNGB1 C-terminal antibody (green) and DAPI. CNGB1 full length protein is not detected in the affected sample. Panels E and F are stained with CNGA1 antibody (green) and DAPI. CNGA1 is not detected in the affected sample, presumably due to necessity for CNGB1 to form viable channels and normal trafficking. Size bar: 20 µm. OS- photoreceptor outer segment, IS – photoreceptor inner segment, ONL – outer nuclear layer, IPL – inner plexiform layer, INL – inner nuclear layer.</p>