Differences between the PubMed record and full-text methods section in in-vivo animal research articles Emily Mazure Melissa Ratajeski Karen Gau Erica Brody Brandi Tuttle 10.6084/m9.figshare.7697816.v2 https://figshare.com/articles/dataset/Differences_between_the_PubMed_record_and_full-text_methods_section_in_in-vivo_animal_research_articles/7697816 <div>Large animal protocols submitted to Institutional Animal Care and Use Committees (IACUCs) are required to include searches for alternatives and address the “3Rs": <br></div><div><br></div><div>1. Refinement: use methodology and protocols that reduce pain and distress<br></div><div>2. Replacement: substitute animals with non-animal models or lower species<br></div><div>3. Reduction: minimize the number of animals </div><div><br></div><div>Locating descriptions of methodology for the refinement concept is challenging since PubMed (and most other databases) do not search full-text. </div><div><br></div><div>The objectives of this study were to determine how well the title, abstract, and MeSH terms cover the content of the methods section in in-vivo animal research articles, particularly with respect to procedures, drugs, and animal species used, and to describe how this might impact a search.</div><div><br></div><div>The title/abstract, MeSH terms, and methods section of each article were reviewed and details such as: animal species, number of animals, description of housing, description of experimental procedures used, and analgesia/anesthesia were extracted. <br></div><div><br></div><div>Articles were screened from April 2017 - September 2017. <br></div><div><br></div><div>Details for the methodology used and description of uploaded files are provided in the README.txt file. <br></div> 2019-03-25 15:34:23 Institutional Animal Care and Use Committee IACUC Laboratory Animals Medical Subject Headings Database searching PubMed Library and Information Studies