Differences between the PubMed record and full-text methods section in in-vivo animal research articles
Emily Mazure
Melissa Ratajeski
Karen Gau
Erica Brody
Brandi Tuttle
10.6084/m9.figshare.7697816.v2
https://figshare.com/articles/dataset/Differences_between_the_PubMed_record_and_full-text_methods_section_in_in-vivo_animal_research_articles/7697816
<div>Large animal protocols submitted to
Institutional Animal Care and Use Committees (IACUCs) are required to include
searches for alternatives and address the “3Rs": <br></div><div><br></div><div>1. Refinement:
use methodology and protocols that reduce pain and distress<br></div><div>2. Replacement:
substitute animals with non-animal models or lower species<br></div><div>3. Reduction:
minimize the number of animals
</div><div><br></div><div>Locating
descriptions of methodology for the refinement concept is challenging since
PubMed (and most other databases) do not search full-text.
</div><div><br></div><div>The objectives of
this study were to determine how well the title, abstract, and
MeSH terms cover the content of the methods section in in-vivo animal
research articles, particularly with respect to procedures, drugs, and
animal species used, and to describe how this might impact a search.</div><div><br></div><div>The title/abstract, MeSH
terms, and methods section of each article were reviewed and details
such as: animal species, number of animals, description of housing,
description of experimental procedures used, and analgesia/anesthesia
were extracted. <br></div><div><br></div><div>Articles were screened from April 2017 - September 2017. <br></div><div><br></div><div>Details for the methodology used and description of uploaded files are provided in the README.txt file. <br></div>
2019-03-25 15:34:23
Institutional Animal Care and Use Committee
IACUC
Laboratory Animals
Medical Subject Headings
Database searching
PubMed
Library and Information Studies