DSB-2 and SUN-1 S8P persist when CO formation is impaired. Simona Rosu Karl A. Zawadzki Ericca L. Stamper Diana E. Libuda Angela L. Reese Abby F. Dernburg Anne M. Villeneuve 10.1371/journal.pgen.1003674.g009 https://plos.figshare.com/articles/figure/_DSB_2_and_SUN_1_S8P_persist_when_CO_formation_is_impaired_/767730 <p>Immunofluorescence images of gonads of indicated genotypes from the distal pre-meiotic region to end of pachytene, stained with DAPI and antibodies that recognize DSB-2 and SUN-1 S8P. The zone of DSB-2 and SUN-1 S8P-positive nuclei is extended in: (A) the <i>syp-1</i> mutant, which is defective for SC formation and for formation of interhomolog COs; and (B, C and D) the <i>zhp-3</i>, <i>msh-5</i> and <i>cosa-1</i> mutants, respectively, which are proficient for synapsis and DNA repair but are defective in conversion of DSBs to COs. Scale bar, 15 µm.</p> 2013-08-08 02:43:31 sun-1 s8p co