10.1021/acs.joc.8b02977.s001
Yuanyong Yang
Yuanyong
Yang
Yingxian Li
Yingxian
Li
Cheng Cheng
Cheng
Cheng
Guo Yang
Guo
Yang
Shuiying Wan
Shuiying
Wan
Jiquan Zhang
Jiquan
Zhang
Yuanhu Mao
Yuanhu
Mao
Yonglong Zhao
Yonglong
Zhao
Lin Zhang
Lin
Zhang
Chun Li
Chun
Li
Lei Tang
Lei
Tang
Reductant-Free Aerobic
Hydroxylation of Isoquinoline-1,3(2<i>H</i>,4<i>H</i>)‑dione Derivatives
American Chemical Society
2019
dione
Base-catalyzed
Derivative
hydroxylation
methodology
Isoquinoline
hydroxylated tetrahydroisoquinoline core structure
heteroaryl
Reductant-Free Aerobic Hydroxylation
transition-metal-free
substrate
reductant-free conditions
alkyl groups
aryl
reductive process
2019-01-15 00:00:00
Journal contribution
https://acs.figshare.com/articles/journal_contribution/Reductant-Free_Aerobic_Hydroxylation_of_Isoquinoline-1_3_2_i_H_i_4_i_H_i_dione_Derivatives/7646996
Base-catalyzed
efficient hydroxylation of isoquinoline-1,3(2<i>H</i>,4<i>H</i>)-diones with air under transition-metal-free
and reductant-free conditions was established. This methodology is
essentially mild and compatible with a broad range of substrates,
including aryl, heteroaryl, and alkyl groups. Also, the product could
be simply transformed into a hydroxylated tetrahydroisoquinoline core
structure through a reductive process.