10.1371/journal.pone.0071645.g002 Tatsushi Miyazaki Tatsushi Miyazaki Satsuki Miyazaki Satsuki Miyazaki Masafumi Ashida Masafumi Ashida Tomofumi Tanaka Tomofumi Tanaka Fumi Tashiro Fumi Tashiro Jun-ichi Miyazaki Jun-ichi Miyazaki Effects of <i>Tcl1</i> deficiency and overexpression on ES-cell differentiation. Public Library of Science 2013 developmental biology Molecular development signaling stem cells Cell potency Embryonic stem cells Cell differentiation Cell fate determination embryology Molecular cell biology Signal transduction Signaling cascades Akt signaling cascade Wnt signaling cascade Signaling in cellular processes Beta-catenin signaling Signaling pathways Catenin signal transduction deficiency overexpression es-cell 2013-08-05 03:35:10 Figure https://plos.figshare.com/articles/figure/_Effects_of_Tcl1_deficiency_and_overexpression_on_ES_cell_differentiation_/764246 <p>The expression of representative stem and differentiation markers was examined by real time PCR in ES cells grown in LIF(+) culture (left half of each panel) and with EB formation (right half of each panel). For EB formation, trypsinized ES cells were seeded into a bacterial grade dish, and cultured for 12 days. Values are expressed as mean ± SEM of three technical replicates. ∗<i>P</i><0.05 and ∗∗<i>P</i><0.01 by Student’s t-test. <i>Tcl1<sup>−/−</sup></i> (KO) vs. wild-type (WT) or <i>Tcl1<sup>−/−</sup></i>(CAG-<i>Tcl1</i>) cells.</p>