Zhao, Yu Li, Chenglong Wang, Ming Su, Liping Qu, Ying Li, Jianfang Yu, Beiqin Yan, Min Yu, Yingyan Liu, Bingya Zhu, Zhenggang Decrease of miR-202-3p Expression, a Novel Tumor Suppressor, in Gastric Cancer <div><p>Emerging studies have indicated that microRNAs are involved in the development and progression of cancer. Here we found that miR-202-3p was frequently down-regulated in gastric cancer tissues. Overexpression of miR-202-3p in gastric cancer cells MKN-28 and BGC-823, markedly suppressed cell proliferation and induced cell apoptosis both <i>in vitro</i> and <i>in vivo</i>. Furthermore, Gli1 expression was frequently positive in gastric cancer tissues and inversely correlated with miR-133b expression. We demonstrate that the transcriptional factor Gli1 was a target of miR-202-3p and plays an essential role as a mediator of the biological effects of miR-202-3p in gastric cancer. MiR-202-3p also inhibited the expression of γ-catenin and BCL-2. Taken together, these findings suggest that miR-202-3p may function as a novel tumor suppressor in gastric cancer and its anti-tumor activity may attribute the direct targeting and inhibition of Gli1.</p></div> Biochemistry;Nucleic acids;rna;RNA interference;genetics;Cancer genetics;Model organisms;Animal models;mouse;Gastroenterology and hepatology;Gastrointestinal cancers;oncology;Basic cancer research;Cancer treatment;mir-202-3p;gastric 2013-07-25
    https://plos.figshare.com/articles/dataset/_Decrease_of_miR_202_3p_Expression_a_Novel_Tumor_Suppressor_in_Gastric_Cancer_/755575
10.1371/journal.pone.0069756