Zhang, Jie Akihisa, Toshihiro Kurita, Masahiro Kikuchi, Takashi Zhu, Wan-Fang Ye, Feng Dong, Zhen-Huan Liu, Wen-Yuan Feng, Feng Xu, Jian Melanogenesis-Inhibitory and Cytotoxic Activities of Triterpene Glycoside Constituents from the Bark of Albizia procera Five oleanane-type triterpene glycosides including three new ones, proceraosides E–G (<b>1</b>–<b>3</b>), were isolated from a MeOH-soluble extract of Albizia procera bark. The structures of <b>1</b>–<b>3</b> were determined by use of NMR spectra, HRESIMS, and chemical methods. Compounds <b>1</b>–<b>5</b> exhibited inhibitory activities against the proliferation of the A549, SKBR3, AZ521, and HL60 human cancer cell lines (IC<sub>50</sub> 0.28–1.8 μM). Additionally, the apoptosis-inducing activity of compound <b>2</b> was evaluated by Hoechst 33342 staining and flow cytometry, while the effects of <b>2</b> on the activation of caspases-9, -8, and -3 in HL60 cells were revealed by Western blot analysis. MeOH-soluble;Cytotoxic Activities;compound 2;HL 60 cells;activation;-3;Albizia procera bark;Western blot analysis;flow cytometry;Compound;proliferation;caspase;NMR spectra;SKBR;Bark;one;HL 60;apoptosis-inducing activity;oleanane-type triterpene glycosides;Albizia procera;Melanogenesis-Inhibitory;cancer cell lines;Hoechst 33342 staining;proceraoside;IC;AZ;Triterpene Glycoside Constituents;HRESIMS;chemical methods 2018-12-06
    https://acs.figshare.com/articles/journal_contribution/Melanogenesis-Inhibitory_and_Cytotoxic_Activities_of_Triterpene_Glycoside_Constituents_from_the_Bark_of_Albizia_procera/7429604
10.1021/acs.jnatprod.8b00167.s001