Phenanthroline‑<i><sup>t</sup></i>BuOK Promoted
Intramolecular C–H Arylation of Indoles with ArI under Transition-Metal-Free
Conditions
Xiang-Huan Shan
Bo Yang
Hong-Xing Zheng
Jian-Ping Qu
Yan-Biao Kang
10.1021/acs.orglett.8b03449.s001
https://acs.figshare.com/articles/journal_contribution/Phenanthroline_i_sup_t_sup_i_BuOK_Promoted_Intramolecular_C_H_Arylation_of_Indoles_with_ArI_under_Transition-Metal-Free_Conditions/7429481
The
first example of phenanthroline-<i><sup>t</sup></i>BuOK
promoted intramolecular radical C–H arylation of <i>N</i>-(2-iodobenzyl)indoles without involvement of transition
metals has been developed. A variety of substituted 6<i>H</i>-isoindolo [2, 1-a] indoles were prepared by a simple and efficient
intramolecular cyclization using 1,10-phenanthroline in the presence
of potassium <i>tert-</i>butoxide and chlorobenzene. This
strategy provides a fast and versatile access to isoindolo[2,1-<i>a</i>]indole derivatives for the synthesis of pharmaceuticals
and organic electroluminescent (EL) materials.
2018-12-06 13:19:00
Indole
potassium tert
phenanthroline
chlorobenzene
transition metals
indole
Arylation
variety
isoindolo
access
strategy
electroluminescent
derivative
synthesis
EL
arylation
pharmaceutical
Transition-Metal-Free Conditions
presence
material
6 H
t BuOK
Promoted
ArI
intramolecular cyclization
Phenanthroline
butoxide
iodobenzyl
Intramolecular
involvement
1-