(±) Gancochlearols A and B: cytotoxic and COX-2 inhibitory meroterpenoids from <i>Ganoderma cochlear</i> Fu-Ying Qin Yong-Ming Yan Zheng-Chao Tu Yong-Xian Cheng 10.6084/m9.figshare.7428890.v1 https://tandf.figshare.com/articles/journal_contribution/_Gancochlearols_A_and_B_cytotoxic_and_COX-2_inhibitory_meroterpenoids_from_i_Ganoderma_cochlear_i_/7428890 <p>(+)- and (−)-gancochlearols A (<b>1</b>) and B (<b>2</b>), two pairs of dimeric mertoterpenoid enantiomers were isolated from the fruiting bodies of <i>Ganoderma cochlear</i>. Their structures were identified by spectroscopic methods. Biological assessments show that the enantiomers of <b>1</b> and <b>2</b> are cytotoxic against three human cancer cell lines (A549, K562, Huh-7) and could inhibit COX-2 expression with IC<sub>50</sub> values less than 10 <i>μ</i>M.</p> <p></p> 2018-12-06 06:33:36 Ganoderma cochlear meroterpenoids cytotoxic activity COX-2