Spatial variation in phosphagens concentration in cross section 1. Shouryadipta Ghosh Kenneth Tran Lea M. D. Delbridge Anthony J. R. Hickey Eric Hanssen Edmund J. Crampin Vijay Rajagopal 10.1371/journal.pcbi.1006640.g006 https://plos.figshare.com/articles/figure/Spatial_variation_in_phosphagens_concentration_in_cross_section_1_/7427324 <p>(A): Phosphagen concentrations were calculated at all the myofibril points in the mesh and subtracted from the spatially averaged concentration of each phosphagen (Phosg<sub>ave</sub>). Box plots represent the statistical distribution of the difference between phosphagen concentration at each point and Phosg<sub>ave</sub> value of each phosphagen. The zero value corresponds to the Phosg<sub>ave</sub>. (B): Normalized concentration of PCr and Cr displayed as a function of local mitochondrial density at various points in the cell. PCr and Cr concentrations were normalized by a factor equivalent to the difference of PCr and Cr maximum and minimum concentrations in cross section 1.</p> 2018-12-05 19:09:30 mitochondrial CK enzymes impact electron microscope images metabolite distributions creatine phosphate bioenergetic mitochondria aggregated mitochondrial distributions force production mitochondrial arrangement twitch duration reactions act cell cross-section cell architecture force dynamics mitochondrial organization uniform force dynamics diffusion hypoxia activity uniform ATP creatine kinase element modeling electron microscopy data PCr shuttle mitochondrial organisation force generation ADP ratios phosphate compounds