Model assumptions and FE mesh generation from EM image cross-sections. Shouryadipta Ghosh Kenneth Tran Lea M. D. Delbridge Anthony J. R. Hickey Eric Hanssen Edmund J. Crampin Vijay Rajagopal 10.1371/journal.pcbi.1006640.g003 https://plos.figshare.com/articles/figure/Model_assumptions_and_FE_mesh_generation_from_EM_image_cross-sections_/7427315 <p>(A): We assumed that individual mitochondria that cluster together will share a common inner membrane space. (B): Based on this assumption, each mitochondrial cluster was divided into two regions: an IMS region, depicted in green and a matrix region, depicted in blue. A third region depicted in red covers the myofibrils present in the cell. (C): Image of a FE mesh developed from the EM image of cross-section 1 with the three different regions.</p> 2018-12-05 19:09:30 mitochondrial CK enzymes impact electron microscope images metabolite distributions creatine phosphate bioenergetic mitochondria aggregated mitochondrial distributions force production mitochondrial arrangement twitch duration reactions act cell cross-section cell architecture force dynamics mitochondrial organization uniform force dynamics diffusion hypoxia activity uniform ATP creatine kinase element modeling electron microscopy data PCr shuttle mitochondrial organisation force generation ADP ratios phosphate compounds