%0 Journal Article %A Tiwari, Keshri Nath %A Thakar, Snehal Rajendra %A Kumar, Vaneet %A Prabhakaran, S. M. %D 2018 %T Catalyst-free synthesis of 3-substituted-3-hydroxy-2-oxindoles by reaction of isatin and cyclic enaminone in water %U https://tandf.figshare.com/articles/journal_contribution/Catalyst-free_synthesis_of_3-substituted-3-hydroxy-2-oxindoles_by_reaction_of_isatin_and_cyclic_enaminone_in_water/7314557 %R 10.6084/m9.figshare.7314557.v1 %2 https://ndownloader.figshare.com/files/13513640 %K Dimedone %K enaminone %K isatin %K oxindole %K water %X

An easy protocol for the synthesis of enaminone attached 3-substituted-3-hydroxy-2-oxindoles has been demonstrated by reaction of isatin and cyclic enaminone in water. The developed catalyst-free reaction has the advantage of being atom-economical, eco-friendly, and benign reaction conditions. The broader substrate scope, experimentally simple procedures, and easy purification of products with high yield further make this method attractive and useful.

%I Taylor & Francis