10.3389/fnhum.2018.00405.s001
Domenico Zacà
Domenico
Zacà
Francesco Corsini
Francesco
Corsini
Umberto Rozzanigo
Umberto
Rozzanigo
Monica Dallabona
Monica
Dallabona
Paolo Avesani
Paolo
Avesani
Luciano Annicchiarico
Luciano
Annicchiarico
Luca Zigiotto
Luca
Zigiotto
Giovanna Faraca
Giovanna
Faraca
Franco Chioffi
Franco
Chioffi
Jorge Jovicich
Jorge
Jovicich
Silvio Sarubbo
Silvio
Sarubbo
Data_Sheet_1_Whole-Brain Network Connectivity Underlying the Human Speech Articulation as Emerged Integrating Direct Electric Stimulation, Resting State fMRI and Tractography.docx
Frontiers
2018
speech
articulation
network
functional connectivity
resting state fMRI
tractography
2018-10-11 14:47:49
Dataset
https://frontiersin.figshare.com/articles/dataset/Data_Sheet_1_Whole-Brain_Network_Connectivity_Underlying_the_Human_Speech_Articulation_as_Emerged_Integrating_Direct_Electric_Stimulation_Resting_State_fMRI_and_Tractography_docx/7195697
<p>Production of fluent speech in humans is based on a precise and coordinated articulation of sounds. A speech articulation network (SAN) has been observed in multiple brain studies typically using either neuroimaging or direct electrical stimulation (DES), thus giving limited knowledge about the whole brain structural and functional organization of this network. In this study, seven right-handed patients underwent awake surgery resection of low-grade gliomas (4) and cavernous angiomas. We combined pre-surgical resting state fMRI (rs-fMRI) and diffusion MRI together with speech arrest sites obtained intra-operatively with DES to address the following goals: (i) determine the cortical areas contributing to the intrinsic functional SAN using the speech arrest sites as functional seeds for rs-fMRI; (ii) evaluate the relative contribution of gray matter terminations from the two major language dorsal stream bundles, the superior longitudinal fasciculus (SLF III) and the arcuate fasciculus (AF); and (iii) evaluate the possible pre-surgical prediction of SAN with rs-fMRI. In all these right-handed patients the intrinsic functional SAN included frontal, inferior parietal, temporal, and insular regions symmetrically and bilaterally distributed across the two hemispheres regardless of the side (four right) of speech arrest evocation. The SLF III provided a much higher density of terminations in the cortical regions of SAN in respect to AF. Pre-surgical rs-fMRI data demonstrated moderate ability to predict the SAN. The set of functional and structural data provided in this multimodal study characterized, at a whole-brain level, a distributed and bi-hemispherical network subserving speech articulation.</p>