NSCL/P patterns of co-expression are associated with DNA repair, and suggest E2F1 as a regulator.
Gerson Shigeru Kobayashi
Lucas Alvizi
Daniele Yumi Sunaga
Philippa Francis-West
Anna Kuta
Bruno Vinícius Pimenta Almada
Simone Gomes Ferreira
Leonardo Carmo de Andrade-Lima
Daniela Franco Bueno
Cássio Eduardo Raposo-Amaral
Carlos Frederico Menck
Maria Rita Passos-Bueno
10.1371/journal.pone.0065677.g002
https://plos.figshare.com/articles/figure/_NSCL_P_patterns_of_co_expression_are_associated_with_DNA_repair_and_suggest_E2F1_as_a_regulator_/718070
<p>(A) Supervised similarity cluster based on <i>BRCA1</i> expression (avg. homogeneity = 0.974). Transcription factor binding sites significantly over-represented in the cluster are marked in grey, for each motif identified (Bonferroni-adjusted p-value <0.05). (B) GO attributes enriched in the similarity cluster and their respective representation among the 30 clustered genes, expressed in percentages ([*] Bootstrap-adjusted p-values = 0.001, raw p-values were used in the chart). (C) Analysis of transcription factor-gene interactions. ChIP-chip data from FANTOM4 were used to validate the interaction between E2F1 and 23 out of the 30 genes of the similarity cluster. The thickness of the arrows indicates how often the interaction has been experimentally detected; node colours represent the level of expression in the cell lines used to assemble the database, from low (light) to high (dark).</p>
2013-06-12 02:14:30
Biochemistry
Nucleic acids
dna
DNA repair
developmental biology
morphogenesis
Birth defects
stem cells
genetics
Molecular genetics
Gene regulation
gene expression
Gene networks
Genetics of disease
Human genetics
patterns
co-expression
e2f1