%0 Generic %A N., Takahashi %A H., Matsushita %A R., Umezawa %A T., Yamamoto %A Y., Ishikawa %A Y., Katagiri %A S., Tasaka %A K., Takeda %A K., Fukui %A N., Kadoya %A K., Ito %A K., Jingu %D 2018 %T Supplementary Material for: Hypofractionated Radiotherapy for Anaplastic Thyroid Carcinoma: 15 Years of Experience in a Single Institution %U https://karger.figshare.com/articles/dataset/Supplementary_Material_for_Hypofractionated_Radiotherapy_for_Anaplastic_Thyroid_Carcinoma_15_Years_of_Experience_in_a_Single_Institution/7165479 %R 10.6084/m9.figshare.7165479.v1 %2 https://ndownloader.figshare.com/files/13182677 %K Anaplastic thyroid carcinoma %K Hypofractionated radiotherapy %K Radiotherapy %K Radiation therapy %X Background: Anaplastic thyroid carcinoma (ATC) is a rare cancer and has a poor prognosis. Several radiation protocols have been reported, but the results were not satisfactory. Objective: The aim of this study was to determine the effect of hypofractionated radiotherapy. Methods: Thirty-three patients who received radiotherapy for ATC between January 2000 and December 2014 were retrospectively included. We defined hypofractionated radiotherapy as a single dose ≥5 Gy. Results: Nineteen patients were treated with hypofractionated radiotherapy. Twenty-eight patients died, and 27 of those patients died from ATC. Sixteen patients died from distant metastasis and 6 from local recurrence. In the hypofractionated radiotherapy group, local recurrence occurred in 5 patients and 1 of them died from active bleeding from a local tumor. There was local recurrence in 7 patients who received the other protocol, and 5 of them died from asphyxiation, active bleeding, or uncontrollable growth of a local tumor on the neck. The median overall survival (OS) was 5 months. In multivariate analysis, patients who received an equivalent dose in 2-Gy fractions (EQD2) ≥50 Gy had significantly better OS (p = 0.016). In univariate analysis, patients who received hypofractionated radiotherapy did not have significantly better OS (p = 0.872) or local control (p = 0.090). The χ2 test showed that significantly fewer patients died from local recurrence in the hypofractionated radiotherapy group (p = 0.025). Conclusions: Multivariate analysis showed that an EQD2 ≥50 Gy resulted in better OS, and hypofractionated radiotherapy decreased the rate of mortality from local recurrence. %I Karger Publishers