%0 Generic
%A N., Takahashi
%A H., Matsushita
%A R., Umezawa
%A T., Yamamoto
%A Y., Ishikawa
%A Y., Katagiri
%A S., Tasaka
%A K., Takeda
%A K., Fukui
%A N., Kadoya
%A K., Ito
%A K., Jingu
%D 2018
%T Supplementary Material for: Hypofractionated Radiotherapy for Anaplastic Thyroid Carcinoma: 15 Years of Experience in a Single Institution
%U https://karger.figshare.com/articles/dataset/Supplementary_Material_for_Hypofractionated_Radiotherapy_for_Anaplastic_Thyroid_Carcinoma_15_Years_of_Experience_in_a_Single_Institution/7165479
%R 10.6084/m9.figshare.7165479.v1
%2 https://ndownloader.figshare.com/files/13182677
%K Anaplastic thyroid carcinoma
%K Hypofractionated radiotherapy
%K Radiotherapy
%K Radiation therapy
%X Background: Anaplastic thyroid carcinoma (ATC) is a rare cancer and has a poor prognosis. Several radiation protocols have been reported, but the results were not satisfactory. Objective: The aim of this study was to determine the effect of hypofractionated radiotherapy. Methods: Thirty-three patients who received radiotherapy for ATC between January 2000 and December 2014 were retrospectively included. We defined hypofractionated radiotherapy as a single dose ≥5 Gy. Results: Nineteen patients were treated with hypofractionated radiotherapy. Twenty-eight patients died, and 27 of those patients died from ATC. Sixteen patients died from distant metastasis and 6 from local recurrence. In the hypofractionated radiotherapy group, local recurrence occurred in 5 patients and 1 of them died from active bleeding from a local tumor. There was local recurrence in 7 patients who received the other protocol, and 5 of them died from asphyxiation, active bleeding, or uncontrollable growth of a local tumor on the neck. The median overall survival (OS) was 5 months. In multivariate analysis, patients who received an equivalent dose in 2-Gy fractions (EQD2) ≥50 Gy had significantly better OS (p = 0.016). In univariate analysis, patients who received hypofractionated radiotherapy did not have significantly better OS (p = 0.872) or local control (p = 0.090). The χ2 test showed that significantly fewer patients died from local recurrence in the hypofractionated radiotherapy group (p = 0.025). Conclusions: Multivariate analysis showed that an EQD2 ≥50 Gy resulted in better OS, and hypofractionated radiotherapy decreased the rate of mortality from local recurrence.
%I Karger Publishers