10.6084/m9.figshare.7058036.v1
Rima Obeid
Rima
Obeid
Christiane Schön
Christiane
Schön
Manfred Wilhelm
Manfred
Wilhelm
Klaus Pietrzik
Klaus
Pietrzik
Stefan Pilz
Stefan
Pilz
Dietary and lifestyle predictors of folate insufficiency in non-supplemented German women
Taylor & Francis Group
2018
Folate intake
RBC-folate
preconceptional
pregnancy
2018-09-07 08:09:47
Journal contribution
https://tandf.figshare.com/articles/journal_contribution/Dietary_and_lifestyle_predictors_of_folate_insufficiency_in_non-supplemented_German_women/7058036
<p>Low folate status is a risk factor for birth defects. We studied concentrations of red blood cell (RBC)- and serum folate in 198 German women in relation to information on dietary folate intake, demographic and lifestyle factors. Median serum- and RBC-folate levels were; (14.7 and 589 nmol/L, respectively. Serum < 7.0 nmol/L or RBC-folate < 405 nmol/L were observed in 3.5% and 18.7% of the women, respectively. Three per cent of the women had both lowered serum and RBC-folate. Whereas RBC-folate > 952 nmol/L (optimal levels around conception) were observed in 9.6%. Serum- and RBC-folate were positively associated; they showed the expected correlations with homocysteine, but only weak correlations with folate intake. Younger age, lower fibre and higher carbohydrate intakes were associated with lower blood folate. Thus, folate intake of approximately 278 µg/d was not sufficient to achieve optimal folate status in young women. In conclusion, in the absence of fortification with folic acid, the majority of the women did not achieve folate status that is optimal for prevention of birth defects.</p>