10.26180/5b90aea79cdf8 ANDREW TANG ANDREW TANG Novel Compounds for Anti-Cancer Directed Enzyme Prodrug Therapy Utilising Nitroreductase Monash University 2018 Nitroreductase Prodrug Bioreduction Medicinal and Biomolecular Chemistry not elsewhere classified 2018-09-06 04:35:50 Thesis https://bridges.monash.edu/articles/thesis/Novel_Compounds_for_Anti-Cancer_Directed_Enzyme_Prodrug_Therapy_Utilising_Nitroreductase/7053089 Cancer is a disease with global impact and there is a constant need to develop new treatments to target it. One method is to take potent drugs and activate them at the tumour. We’ve been working on a strategy that will release potent drugs only when activated by a specific enzyme which can be delivered to the tumour. We have success designed a chemical system that only releases the payload in the presence of the enzyme. We hope that this design will be used to make anti-cancer drugs safer.