%0 Figure %A Kosaka, Junko %A Morimatsu, Hiroshi %A Takahashi, Toru %A Shimizu, Hiroko %A Kawanishi, Susumu %A Omori, Emiko %A Endo, Yasumasa %A Tamaki, Naofumi %A Morita, Manabu %A Morita, Kiyoshi %D 2013 %T Effect of BV administration after hemorrhagic shock and resuscitation (HSR) in the lungs. %U https://plos.figshare.com/articles/figure/_Effect_of_BV_administration_after_hemorrhagic_shock_and_resuscitation_HSR_in_the_lungs_/698710 %R 10.1371/journal.pone.0063606.g007 %2 https://ndownloader.figshare.com/files/1054775 %K Biochemistry %K drug discovery %K Molecular cell biology %K Cellular stress responses %K Clinical immunology %K immunity %K inflammation %K Critical care and emergency medicine %K Drugs and devices %K Clinical pharmacology %K Drug research and development %K Pulmonology %K bv %K hemorrhagic %K resuscitation %X

The rats were randomly divided into two groups: a HSR/Vehicle group, which was administered vehicle after HSR, and a HSR/BV group, which was administered BV after HSR. BV (35 mg/kg) or vehicle was injected via the femoral vein after resuscitation. (A) Representative images from five independent experiments (hematoxylin–eosin staining, original magnification ×200, scale bar  = 100 µm). (B) lung histopathological score 12 h after HSR. (C) Mitochondrial 8-OHdG levels in the lungs 3 h after HSR. Data are presented as means ± standard deviation (n = 5 per group). Statistical analysis was performed using Student’s t-test. *p<0.05 vs. HSR/Vehicle.

%I PLOS ONE