Enantioselective total syntheses of (−)-clavaminol A and deacetyl (+)-clavaminol H
Rachana Pandey
Anju Gehlawat
Ranjana Prakash
Satyendra Kumar Pandey
10.6084/m9.figshare.6955058.v1
https://tandf.figshare.com/articles/journal_contribution/Enantioselective_total_syntheses_of_-clavaminol_A_and_deacetyl_-clavaminol_H/6955058
<p>An efficient enantioselective approach to the syntheses of (−)-clavaminol A and deacetyl (+)-clavaminol H is presented, starting from <i>n</i>-decanol. The synthesis features Sharpless asymmetric dihydroxylation (AD), regioselective epoxide formation/opening and <i>α</i>-tosylation as key steps.</p>
2018-08-10 13:34:57
2-amino-3-alkanols
clavaminols
cytotoxic
Sharpless AD
regioselective