Coupling of Carboxylic Acids with Ynamides and Subsequent Rearrangement for the Synthesis of Imides/Amides Yangyong Shen Qi Li Gang Xu Sunliang Cui 10.1021/acs.orglett.8b02134.s001 https://acs.figshare.com/articles/journal_contribution/Coupling_of_Carboxylic_Acids_with_Ynamides_and_Subsequent_Rearrangement_for_the_Synthesis_of_Imides_Amides/6954848 A coupling of carboxylic acids with ynamides and subsequent rearrangement for the synthesis of imides and amides is reported. The carboxylic acids could couple with ynamides to form α-acyloxyenamide followed by sulfonyl group migration and Mumm rearrangement to furnish the amides. Additionally, the products could be subjected to further rearrangement to deliver β-keto amides. This metal-free process represents an interesting method for chemical bonds cleavage and regeneration. Furthermore, divergent transformation of products were conducted to deliver an array of compounds. 2018-08-10 11:19:02 carboxylic acids ynamide sulfonyl group migration form α- acyloxyenamide chemical bonds cleavage β- keto amides rearrangement