10.1371/journal.pone.0202354.g003
Natalia Di Pietro
Natalia
Di Pietro
Maria Assunta Potenza
Maria
Assunta Potenza
Sara Di Silvestre
Sara Di
Silvestre
Francesco Addabbo
Francesco
Addabbo
Nadia Di Pietrantonio
Nadia
Di Pietrantonio
Pamela Di Tomo
Pamela
Di Tomo
Caterina Pipino
Caterina
Pipino
Domitilla Mandatori
Domitilla
Mandatori
Carola Palmerini
Carola
Palmerini
Paola Failli
Paola
Failli
Mario Bonomini
Mario
Bonomini
Monica Montagnani
Monica
Montagnani
Assunta Pandolfi
Assunta
Pandolfi
Effect of endothelium removal and CaSR inhibition on vascular response to R-568.
Public Library of Science
2018
L-NAME
CaSR
Spontaneously Hypertensive rats
Calcimimetic R -568 vasodilatory effect
SHR
CTX
muscle cells
MVB
eNOS phosphorylation levels
R -568 concentration
MBV
calcimimetic R -568
WKY
R -568 doses
INDO
2018-08-09 17:58:23
Figure
https://plos.figshare.com/articles/figure/Effect_of_endothelium_removal_and_CaSR_inhibition_on_vascular_response_to_R-568_/6952922
<p>(A) MVB isolated from 8-week old WKY (closed symbols) and SHR (open symbols) were stimulated with increasing concentrations of R-568 in the presence (circles) or in the absence (squares) of endothelium. Results shown are the mean ± SEM of 3 (WKY) and 3 (SHR) independent experiments. Data from each curve were normalized as in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0202354#pone.0202354.g001" target="_blank">Fig 1</a>. (B) MVB isolated from 8-week old WKY (closed symbols) and SHR (open symbols) were stimulated with increasing concentrations of R-568 in the absence (circles) or after pretreatment with (diamonds) Calhex-231 (3 μM/20 min). Results are the mean ± SEM of 3 WKY and 3 SHR independent experiments. Data from each curve were normalized as in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0202354#pone.0202354.g001" target="_blank">Fig 1</a>. *p < 0.05 <i>vs</i> respective CTRL curve.</p>