10.1371/journal.pone.0202354.g001
Natalia Di Pietro
Natalia
Di Pietro
Maria Assunta Potenza
Maria
Assunta Potenza
Sara Di Silvestre
Sara Di
Silvestre
Francesco Addabbo
Francesco
Addabbo
Nadia Di Pietrantonio
Nadia
Di Pietrantonio
Pamela Di Tomo
Pamela
Di Tomo
Caterina Pipino
Caterina
Pipino
Domitilla Mandatori
Domitilla
Mandatori
Carola Palmerini
Carola
Palmerini
Paola Failli
Paola
Failli
Mario Bonomini
Mario
Bonomini
Monica Montagnani
Monica
Montagnani
Assunta Pandolfi
Assunta
Pandolfi
Vascular effects of R-568 in MVB from WKY and SHR rats.
Public Library of Science
2018
L-NAME
CaSR
Spontaneously Hypertensive rats
Calcimimetic R -568 vasodilatory effect
SHR
CTX
muscle cells
MVB
eNOS phosphorylation levels
R -568 concentration
MBV
calcimimetic R -568
WKY
R -568 doses
INDO
2018-08-09 17:58:23
Figure
https://plos.figshare.com/articles/figure/Vascular_effects_of_R-568_in_MVB_from_WKY_and_SHR_rats_/6952916
<p>Mesenteric vascular beds (MVB) from 8-week old WKY and SHR rats were isolated and prepared as described in Methods. PP at approximately 120 mmHg was maintained by continuous infusion with NA (10 μM and 3 μM in WKY and SHR rats, respectively). (A) and (B) Representative tracings of vasodilator responses to submaximal ACh dose (1 μM) and to increasing concentrations of R-568 (10 nM—30 μM) in WKY (A) and SHR (B) are shown. Each symbol represents the start of a 4-min perfusion. (C) Dose-response curves for R-568-induced vascular effects were obtained from MVB of WKY and SHR. Results are the mean ± SEM of 7 (WKY) and 6 (SHR) independent experiments. Data from each curve were normalized by defining 100% as the initial steady state PP and 0% as the maximal reduction in PP obtained in WKY treated with 1 μM ACh. *p < 0.01 <i>vs</i> respective values.</p>