10.1371/journal.pone.0061984.g004 Cong Yan Cong Yan Xinchun Ding Xinchun Ding Lingyan Wu Lingyan Wu Menggang Yu Menggang Yu Peng Qu Peng Qu Hong Du Hong Du ELISA analyses of CHI3L1 protein in BALF and serum of systemic inflammation-induced lung tumor mice. Public Library of Science 2013 Biochemistry histology immunology oncology Cancer detection and diagnosis Early detection chi3l1 balf serum systemic inflammation-induced 2013-04-22 02:11:12 Figure https://plos.figshare.com/articles/figure/_ELISA_analyses_of_CHI3L1_protein_in_BALF_and_serum_of_systemic_inflammation_induced_lung_tumor_mice_/687872 <p>Left: CHI3L1 protein concentrations in BALF and serum of doxycycline-treated and untreated bitransgenic mice. Right: ROC (Receiver Operating Characteristic) curve analyses to determine the area under the curve (AUC). Dox-: doxycycline-untreated mice; Dox+: doxycycline-treated mice without showing lung tumor; Cancer, doxycycline-treated mice with lung tumor. <b>A)</b> c-fms-rtTA/(TetO)<sub>7</sub>-CMV-MMP12 mice. Mean ± SD in BALF (n>7), DOX -: 17.7±13.8, DOX +: 42.1±67.9, Cancer: 70.9±36.5. Mean ± SD in serum (n>7), DOX -: 39.1±25.6, DOX +: 57.7±55.5, Cancer: 232.3±110.6. The gray lines represent the mean values; <b>B)</b> c-fms-rtTA/(TetO)<sub>7</sub>-CMV-Api6 mice. Mean ± SD in BALF (n>6), DOX -: 69.6±16.6, DOX +: 73.2±28.1, Cancer: 189.9±47.2. Mean ± SD in serum (n>6), DOX -: 25.2±7.3, DOX +: 21.0±11.7, Cancer: 69.5±19.1. The gray lines represent the mean values.</p>