10.1371/journal.pone.0061353.g006 Shalom Madar Shalom Madar Einav Harel Einav Harel Ido Goldstein Ido Goldstein Yan Stein Yan Stein Ira Kogan-Sakin Ira Kogan-Sakin Iris Kamer Iris Kamer Hilla Solomon Hilla Solomon Elya Dekel Elya Dekel Perry Tal Perry Tal Naomi Goldfinger Naomi Goldfinger Gilgi Friedlander Gilgi Friedlander Varda Rotter Varda Rotter A schematic representation of the interaction between mutant p53 and the IFNβ pathway. Public Library of Science 2013 genetics gene expression DNA transcription RNA stability Cancer genetics Gene networks Genetic mutation Genetics of disease immunology Immunologic subspecialties Tumor immunology Molecular cell biology Signal transduction Signaling in cellular processes Antiapoptotic signaling Signaling in selected disciplines Oncogenic signaling Clinical immunology oncology Cancers and neoplasms Lung and intrathoracic tumors Adenocarcinoma of the lung schematic mutant p53 2013-04-22 02:10:42 Figure https://plos.figshare.com/articles/figure/_A_schematic_representation_of_the_interaction_between_mutant_p53_and_the_IFN_946_pathway_/687842 <p>Blue arrows denote positive effect while red arrows denote negative effect. Upon encounter with cancer cell CAFs activate the IFNβ pathway which limits cancer cells' migration. When mutant p53 is present in the cancer cells, this pathway is moderated via SOCS1 mediated inhibition of STAT1 phosphorylation. IFNβ is able to reduce mutant p53 RNA levels by attenuating the expression of mutant p53 RNA stabilizer WIG1.</p>