10.1371/journal.pone.0061353.g006
Shalom Madar
Shalom
Madar
Einav Harel
Einav
Harel
Ido Goldstein
Ido
Goldstein
Yan Stein
Yan
Stein
Ira Kogan-Sakin
Ira
Kogan-Sakin
Iris Kamer
Iris
Kamer
Hilla Solomon
Hilla
Solomon
Elya Dekel
Elya
Dekel
Perry Tal
Perry
Tal
Naomi Goldfinger
Naomi
Goldfinger
Gilgi Friedlander
Gilgi
Friedlander
Varda Rotter
Varda
Rotter
A schematic representation of the interaction between mutant p53 and the IFNβ pathway.
Public Library of Science
2013
genetics
gene expression
DNA transcription
RNA stability
Cancer genetics
Gene networks
Genetic mutation
Genetics of disease
immunology
Immunologic subspecialties
Tumor immunology
Molecular cell biology
Signal transduction
Signaling in cellular processes
Antiapoptotic signaling
Signaling in selected disciplines
Oncogenic signaling
Clinical immunology
oncology
Cancers and neoplasms
Lung and intrathoracic tumors
Adenocarcinoma of the lung
schematic
mutant
p53
2013-04-22 02:10:42
Figure
https://plos.figshare.com/articles/figure/_A_schematic_representation_of_the_interaction_between_mutant_p53_and_the_IFN_946_pathway_/687842
<p>Blue arrows denote positive effect while red arrows denote negative effect. Upon encounter with cancer cell CAFs activate the IFNβ pathway which limits cancer cells' migration. When mutant p53 is present in the cancer cells, this pathway is moderated via SOCS1 mediated inhibition of STAT1 phosphorylation. IFNβ is able to reduce mutant p53 RNA levels by attenuating the expression of mutant p53 RNA stabilizer WIG1.</p>