10.6084/m9.figshare.6807206.v1
Zaur M. Kachaev
Zaur M.
Kachaev
Lyubov A. Lebedeva
Lyubov A.
Lebedeva
Eugene N. Kozlov
Eugene N.
Kozlov
Ilya Y. Toropygin
Ilya Y.
Toropygin
Paul Schedl
Paul
Schedl
Yulii V. Shidlovskii
Yulii V.
Shidlovskii
Paip2 is localized to active promoters and loaded onto nascent mRNA in <i>Drosophila</i>
Taylor & Francis Group
2018
Paip2
nucleus
transcription
promoter
mRNA
2018-07-11 19:24:26
Dataset
https://tandf.figshare.com/articles/dataset/Paip2_is_localized_to_active_promoters_and_loaded_onto_nascent_mRNA_in_i_Drosophila_i_/6807206
<p>Paip2 (Poly(A)-binding protein – interacting protein 2) is a conserved metazoan-specific protein that has been implicated in regulating the translation and stability of mRNAs. However, we have found that Paip2 is not restricted to the cytoplasm but is also found in the nucleus in <i>Drosophila</i> embryos, salivary glands, testes, and tissue culture cells. Nuclear Paip2 is associated with chromatin, and in chromatin immunoprecipitation experiments it maps to the promoter regions of active genes. However, this chromatin association is indirect, as it is RNA-dependent. Thus, Paip2 is one more item in the growing list of translation factors that are recruited to mRNAs co-transcriptionally.</p>