%0 Journal Article %A Haouchine, Arslane-Larbi %A Kabri, Youssef %A Bakhta, Saléha %A Curti, Christophe %A Nedjar-Kolli, Bellara %A Vanelle, Patrice %D 2018 %T Simple synthesis of imidazo[1,2-A]pyridine derivatives bearing 2-aminonicotinonitrile or 2-aminochromene moiety %U https://tandf.figshare.com/articles/journal_contribution/Simple_synthesis_of_imidazo_1_2-_i_A_i_pyridine_derivatives_bearing_2-aminonicotinonitrile_or_2-aminochromene_moiety/6804638 %R 10.6084/m9.figshare.6804638.v1 %2 https://ndownloader.figshare.com/files/12375872 %K Aminochromene %K aminopyridine %K green chemistry %K imidazopyridine %K Knoevenagel %X

A simple and general method for the synthesis of new imidazopyridines bearing an aminopyridinyl, chromenyl, or quinolinyl moiety in the C2 position was developed. The Knoevenagel reaction between imidazo[1,2-a]pyridine-2-carbaldehyde 1 and malononitrile resulted in the formation of starting material 2. Subsequently, intramolecular cyclization between the cyano group of 2 and acetophenones, naphtols, hydroxyquinolines, or phenols, gave 3, 4, 5, and 6 compounds, respectively. This is a simple, reproducible, and environmentally friendly method of synthesizing substituted imidazopyridines using water as a solvent or under solvent-free conditions.

%I Taylor & Francis