10.26180/5b3d9484db69b HANNAH PUI YUN LOKE HANNAH PUI YUN LOKE The Regulation and Function of the Y-Chromosome Gene, SRY, in the Healthy and Diseased Male Brain Monash University 2019 Sex differences SRY Parkinson's disease Attention deficit hyperactivity disorder catecholamines Behavioral Neuroscience Cell Neurochemistry Genetics 2019-03-19 04:01:28 Thesis https://bridges.monash.edu/articles/thesis/The_Regulation_and_Function_of_the_Y-Chromosome_Gene_SRY_in_the_Healthy_and_Diseased_Male_Brain/6741944 This thesis investigated the role of a male-specific Y-chromosome gene known as SRY in the male brain. The findings revealed that SRY is involved in the healthy functioning of the male brain. However, high levels of SRY worsen the symptoms in animal models of Parkinson’s disease. In contrast, low levels of SRY contributed to symptoms in an animal model of attention deficit hyperactivity disorder (ADHD). Therefore, the results demonstrate that the misregulation of SRY levels could underlie the male bias in brain disorders such as Parkinson’s disease and ADHD.