10.26180/5b3d9484db69b
HANNAH PUI YUN LOKE
HANNAH PUI YUN
LOKE
The Regulation and Function of the Y-Chromosome Gene, SRY, in the Healthy and Diseased Male Brain
Monash University
2019
Sex differences
SRY
Parkinson's disease
Attention deficit hyperactivity disorder
catecholamines
Behavioral Neuroscience
Cell Neurochemistry
Genetics
2019-03-19 04:01:28
Thesis
https://bridges.monash.edu/articles/thesis/The_Regulation_and_Function_of_the_Y-Chromosome_Gene_SRY_in_the_Healthy_and_Diseased_Male_Brain/6741944
This thesis investigated the role of a male-specific Y-chromosome gene known as SRY in the male brain. The findings revealed that SRY is involved in the healthy functioning of the male brain. However, high levels of SRY worsen the symptoms in animal models of Parkinson’s disease. In contrast, low levels of SRY contributed to symptoms in an animal model of attention deficit hyperactivity disorder (ADHD). Therefore, the results demonstrate that the misregulation of SRY levels could underlie the male bias in brain disorders such as Parkinson’s disease and ADHD.