TY - DATA T1 - Anthracycline-Induced Cardiotoxicity: Understanding the Incidence, Risk Factors and Development of a Prediction Model PY - 2018/07/02 AU - SIEW LIAN LEONG UR - https://bridges.monash.edu/articles/thesis/Anthracycline-Induced_Cardiotoxicity_Understanding_the_Incidence_Risk_Factors_and_Development_of_a_Prediction_Model/6728444 DO - 10.4225/03/5b39989b8a64b L4 - https://ndownloader.figshare.com/files/16355426 KW - Chemotherapy KW - Heart failure KW - Clinical Pharmacy and Pharmacy Practice KW - Pharmacogenomics N2 - In Asia, the incidence of chemotherapy-related cardiovascular complications among cancer patients was 4.7%. In a multi-ethnic population in Asia who were at risk for anthracycline-related cardiotoxicities (ACT) at a lower cumulative dose and a younger age, the incidence of ACT was 4.6%. The four-factor ACT prediction model developed from demographic and clinical characteristics can potentially be use in clinical practice. Genetic studies found that single nucleotide polymorphisms are potential predictors for antineoplastic-related cardiotoxicity such as ABCC2 rs8187710, CYBA rs4673 and RAC2 rs13058338 in ACT. Combination of demographic, clinical and genotypes effects could be the future in predicting chemotherapy-related cardiovascular complications. ER -