Role of Klf11 in endometriosis-associated fibrosis.
Gaurang S. Daftary
Ye Zheng
Zaid M. Tabbaa
John K. Schoolmeester
Ravi P. Gada
Adrienne L. Grzenda
Angela J. Mathison
Gary L. Keeney
Gwen A. Lomberk
Raul Urrutia
10.1371/journal.pone.0060165.g003
https://plos.figshare.com/articles/figure/_Role_of_Klf11_in_endometriosis_associated_fibrosis_/661922
<p>Endometriotic lesions in <i>Klf11-/-</i> mice were associated with prolific <i>de novo</i> scar tissue formation in contrast to wildtype controls. (<b>A</b>) Adhesions in <i>Klf11-/-</i> animals were thick, opaque, dense and unyielding to mechanical disruption by pressure. The adhesions had a broad base (black arrows) and involved adjacent viscera such as the small and large intestine, stomach and liver, thereby resulting in obliteration of physiological tissue planes. (<b>B</b>) Progressive fibrosis further involved the intestinal mesentery in these animals, resulting in straightening of the bowel with apparent shortening of length (white arrows). (<b>C</b>) In contrast, in wildtype animals, the lesions remained discrete (white arrows and box in C and D) with minimal adhesions (black arrow). Any adhesions that formed were slender, transparent, non-obliterating and very easily disrupted by pressure. (<b>D</b>) Lack of progressive and prolific fibrosis in wildtype animals preserved normal intra-abdominal anatomy with no peritoneal obliteration or mesenteric fibrosis.</p>
2013-03-29 09:42:13
klf11
endometriosis-associated