Nickel-Catalyzed Denitrogenative Cross-Coupling Reaction
of 1,2,3-Benzotriazin-4(3<i>H</i>)‑ones with Organoboronic
Acids: An Easy Access to <i>Ortho</i>-Arylated and Alkenylated
Benzamides
Madasamy Hari Balakrishnan
Kotturaja Sathriyan
Subramaniyan Mannathan
10.1021/acs.orglett.8b01401.s001
https://acs.figshare.com/articles/journal_contribution/Nickel-Catalyzed_Denitrogenative_Cross-Coupling_Reaction_of_1_2_3-Benzotriazin-4_3_i_H_i_ones_with_Organoboronic_Acids_An_Easy_Access_to_i_Ortho_i_-Arylated_and_Alkenylated_Benzamides/6509174
A novel nickel-catalyzed approach
to synthesize <i>ortho</i>-arylated and alkenylated benzamides
in good to high yields via a
denitrogenative cross-coupling reaction of 1,2,3-benzotriazin-4(3<i>H</i>)-ones with organoboronic acids is described. The reaction
proceeds through a five-membered azanickelacyclic intermediate with
the extrusion of a nitrogen molecule. Moreover, the resulting <i>ortho</i>-arylated benzamides were successfully converted into
synthetically useful substituted fluorenones and <i>ortho</i>-arylated benzylamine derivatives in high yields.
2018-06-13 12:57:24
nitrogen molecule
Alkenylated Benzamides
one
yield
arylated benzylamine derivatives
novel nickel-catalyzed approach
organoboronic acids
ortho
five-membered azanickelacyclic
arylated benzamides
reaction proceeds
Easy Access
Organoboronic Acids
alkenylated benzamides
Nickel-Catalyzed Denitrogenative Cross-Coupling Reaction
denitrogenative cross-coupling reaction