10.6084/m9.figshare.6505418.v1
Nazanin Asghari Hanjani
Nazanin Asghari
Hanjani
Negar Zamaninour
Negar
Zamaninour
Narjes Najibi
Narjes
Najibi
Agha Fatemeh Hosseini
Agha Fatemeh
Hosseini
Tayebeh Rastegar
Tayebeh
Rastegar
Mohammad Reza Vafa
Mohammad Reza
Vafa
The role of time of food intake on upcoming liver disease in male Wistar rat
Taylor & Francis Group
2018
NAFLD
calorie restriction
circadian food intake
time-restricted feeding
juvenile obesity
visceral fat
HFD: high-fat diet
CON1: first-phase control group
CR: calorie restriction
NIF: night intermittent fasting
DIF: day intermittent fasting
CON2: second-phase control group
SCN: suprachiasmatic nucleus
ZT: zeitgeber
ANONA
ALT: alanine aminotransferase
AST: aspartate aminotransferase
ANOVA: one-way analysis of variance
2018-06-13 04:21:18
Journal contribution
https://tandf.figshare.com/articles/journal_contribution/The_role_of_time_of_food_intake_on_upcoming_liver_disease_in_male_Wistar_rat/6505418
<p>Interventions against obesity, are mainly around changing calorie intake and energy expenditure. Recently, some studies focused on the influence of circadian time of food intake on metabolic status. Here, we compare the role of calorie restriction and time restricted feeding followed by high-fat diet started post weaning, First, 52 male Wistarrats (3 weeks old) were divided into two groups: the high-fat diet (HFD, <i>n</i> = 42) and the control group (CON1, <i>n</i> = 11). After 17 weeks, five rats were randomly selected from each group for sample preparation. In the second phase, the animals in HFD group were assigned into four groups (<i>n</i> = 9): (1) 30% calorie restriction (CR), (2) day intermittent fasting (DIF), (3) night intermittent fasting (NIF), (4) adlibitum food intake (AL), (5) remained animal from the first phase control (CON2). Seventeen weeks of HFD started post-weaning did not cause fatty liver but it caused a significant difference in the body and the adipose tissue weight (P0.05). The results showed that longtime HFD did not lead to liver steatosis while the incorrect time of food intake predisposes the animal to the upcoming liver disease. This data indicate a significant role of timing of food intake rather than nutrition composition itself.</p>