%0 Generic
%A R., Novaković
%A A., Geelen
%A D., Ristić-Medić
%A M., Nikolić
%A O.W., Souverein
%A H., McNulty
%A M., Duffy
%A L., Hoey
%A C., Dullemeijer
%A J.M.S., Renkema
%A M., Gurinović
%A M., Glibetić
%A de Groot L.C.P.G.M.
%A P., van’t Veer
%D 2018
%T Supplementary Material for: Systematic Review of Observational Studies with Dose-Response Meta-Analysis between Folate Intake and Status Biomarkers in Adults and the Elderly
%U https://karger.figshare.com/articles/dataset/Supplementary_Material_for_Systematic_Review_of_Observational_Studies_with_Dose-Response_Meta-Analysis_between_Folate_Intake_and_Status_Biomarkers_in_Adults_and_the_Elderly/6455147
%R 10.6084/m9.figshare.6455147.v1
%2 https://ndownloader.figshare.com/files/11876594
%K Folate
%K Intake-status
%K Dose-response
%K Adults-elderly
%X Background: Dietary reference values for folate intake vary widely across Europe. Methods: MEDLINE and Embase through November 2016 were searched for data on the association between folate intake and biomarkers (serum/plasma folate, red blood cell [RBC] folate, plasma homocysteine) from observational studies in healthy adults and elderly. The regression coefficient of biomarkers on intake (β) was extracted from each study, and the overall and stratified pooled β and SE (β) were obtained by random effects meta-analysis on a double log scale. These dose-response estimates may be used to derive folate intake reference values. Results: For every doubling in folate intake, the changes in serum/plasma folate, RBC folate and plasma homocysteine were +22, +21, and –16% respectively. The overall pooled regression coefficients were β = 0.29 (95% CI 0.21–0.37) for serum/plasma folate (26 estimates from 17 studies), β = 0.28 (95% CI 0.21–0.36) for RBC (13 estimates from 11 studies), and β = –0.21 (95% CI –0.31 to –0.11) for plasma homocysteine (10 estimates from 6 studies). Conclusion: These estimates along with those from randomized controlled trials can be used for underpinning dietary recommendations for folate in adults and elderly.
%I Karger Publishers