%0 Generic %A R., Novaković %A A., Geelen %A D., Ristić-Medić %A M., Nikolić %A O.W., Souverein %A H., McNulty %A M., Duffy %A L., Hoey %A C., Dullemeijer %A J.M.S., Renkema %A M., Gurinović %A M., Glibetić %A de Groot L.C.P.G.M. %A P., van’t Veer %D 2018 %T Supplementary Material for: Systematic Review of Observational Studies with Dose-Response Meta-Analysis between Folate Intake and Status Biomarkers in Adults and the Elderly %U https://karger.figshare.com/articles/dataset/Supplementary_Material_for_Systematic_Review_of_Observational_Studies_with_Dose-Response_Meta-Analysis_between_Folate_Intake_and_Status_Biomarkers_in_Adults_and_the_Elderly/6455147 %R 10.6084/m9.figshare.6455147.v1 %2 https://ndownloader.figshare.com/files/11876594 %K Folate %K Intake-status %K Dose-response %K Adults-elderly %X Background: Dietary reference values for folate intake vary widely across Europe. Methods: MEDLINE and Embase through November 2016 were searched for data on the association between folate intake and biomarkers (serum/plasma folate, red blood cell [RBC] folate, plasma homocysteine) from observational studies in healthy adults and elderly. The regression coefficient of biomarkers on intake (β) was extracted from each study, and the overall and stratified pooled β and SE (β) were obtained by random effects meta-analysis on a double log scale. These dose-response estimates may be used to derive folate intake reference values. Results: For every doubling in folate intake, the changes in serum/plasma folate, RBC folate and plasma homocysteine were +22, +21, and –16% respectively. The overall pooled regression coefficients were β = 0.29 (95% CI 0.21–0.37) for serum/plasma folate (26 estimates from 17 studies), β = 0.28 (95% CI 0.21–0.36) for RBC (13 estimates from 11 studies), and β = –0.21 (95% CI –0.31 to –0.11) for plasma homocysteine (10 estimates from 6 studies). Conclusion: These estimates along with those from randomized controlled trials can be used for underpinning dietary recommendations for folate in adults and elderly. %I Karger Publishers