Motion-Based
Immunological Detection of Zika Virus
Using Pt-Nanomotors and a Cellphone
Mohamed
Shehata Draz
Nivethitha Kota Lakshminaraasimulu
Sanchana Krishnakumar
Dheerendranath Battalapalli
Anish Vasan
Manoj Kumar Kanakasabapathy
Aparna Sreeram
Shantanu Kallakuri
Prudhvi Thirumalaraju
Yudong Li
Stephane Hua
Xu G. Yu
Daniel R. Kuritzkes
Hadi Shafiee
10.1021/acsnano.8b01515.s006
https://acs.figshare.com/articles/media/Motion-Based_Immunological_Detection_of_Zika_Virus_Using_Pt-Nanomotors_and_a_Cellphone/6275849
Zika virus (ZIKV) infection is an
emerging pandemic threat to humans
that can be fatal in newborns. Advances in digital health systems
and nanoparticles can facilitate the development of sensitive and
portable detection technologies for timely management of emerging
viral infections. Here we report a nanomotor-based bead-motion cellphone
(NBC) system for the immunological detection of ZIKV. The presence
of virus in a testing sample results in the accumulation of platinum
(Pt)-nanomotors on the surface of beads, causing their motion in H<sub>2</sub>O<sub>2</sub> solution. Then the virus concentration is detected
in correlation with the change in beads motion. The developed NBC
system was capable of detecting ZIKV in samples with virus concentrations
as low as 1 particle/μL. The NBC system allowed a highly specific
detection of ZIKV in the presence of the closely related dengue virus
and other neurotropic viruses, such as herpes simplex virus type 1
and human cytomegalovirus. The NBC platform technology has the potential
to be used in the development of point-of-care diagnostics for pathogen
detection and disease management in developed and developing countries.
2018-05-16 13:50:46
H 2 O 2 solution
nanomotor-based bead-motion cellphone
Cellphone Zika virus
testing sample results
Motion-Based Immunological Detection
ZIKV
NBC system
detection
herpes simplex virus type 1
NBC platform technology