TY - DATA T1 - Motion-Based Immunological Detection of Zika Virus Using Pt-Nanomotors and a Cellphone PY - 2018/05/16 AU - Mohamed Shehata Draz AU - Nivethitha Kota Lakshminaraasimulu AU - Sanchana Krishnakumar AU - Dheerendranath Battalapalli AU - Anish Vasan AU - Manoj Kumar Kanakasabapathy AU - Aparna Sreeram AU - Shantanu Kallakuri AU - Prudhvi Thirumalaraju AU - Yudong Li AU - Stephane Hua AU - Xu G. Yu AU - Daniel R. Kuritzkes AU - Hadi Shafiee UR - https://acs.figshare.com/articles/media/Motion-Based_Immunological_Detection_of_Zika_Virus_Using_Pt-Nanomotors_and_a_Cellphone/6275837 DO - 10.1021/acsnano.8b01515.s010 L4 - https://ndownloader.figshare.com/files/11477192 KW - H 2 O 2 solution KW - nanomotor-based bead-motion cellphone KW - Cellphone Zika virus KW - testing sample results KW - Motion-Based Immunological Detection KW - ZIKV KW - NBC system KW - detection KW - herpes simplex virus type 1 KW - NBC platform technology N2 - Zika virus (ZIKV) infection is an emerging pandemic threat to humans that can be fatal in newborns. Advances in digital health systems and nanoparticles can facilitate the development of sensitive and portable detection technologies for timely management of emerging viral infections. Here we report a nanomotor-based bead-motion cellphone (NBC) system for the immunological detection of ZIKV. The presence of virus in a testing sample results in the accumulation of platinum (Pt)-nanomotors on the surface of beads, causing their motion in H2O2 solution. Then the virus concentration is detected in correlation with the change in beads motion. The developed NBC system was capable of detecting ZIKV in samples with virus concentrations as low as 1 particle/μL. The NBC system allowed a highly specific detection of ZIKV in the presence of the closely related dengue virus and other neurotropic viruses, such as herpes simplex virus type 1 and human cytomegalovirus. The NBC platform technology has the potential to be used in the development of point-of-care diagnostics for pathogen detection and disease management in developed and developing countries. ER -