Wu, Yili Duan, Haiping Tian, Xiaocao Xu, Chunsheng Wang, Weijing Jiang, Wenjie Pang, Zengchang Zhang, Dongfeng Tan, Qihua Table_2_Genetics of Obesity Traits: A Bivariate Genome-Wide Association Analysis.docx <p>Previous genome-wide association studies on anthropometric measurements have identified more than 100 related loci, but only a small portion of heritability in obesity was explained. Here we present a bivariate twin study to look for the genetic variants associated with body mass index and waist-hip ratio, and to explore the obesity-related pathways in Northern Han Chinese. Cholesky decomposition model for 242 monozygotic and 140 dizygotic twin pairs indicated a moderate genetic correlation (r = 0.53, 95%CI: 0.42–0.64) between body mass index and waist-hip ratio. Bivariate genome-wide association analysis in 139 dizygotic twin pairs identified 26 associated SNPs with p < 10<sup>−5</sup>. Further gene-based analysis found 291 nominally associated genes (P < 0.05), including F12, HCRTR1, PHOSPHO1, DOCK2, DOCK6, DGKB, GLP1R, TRHR, MMP1, GPR55, CCK, and OR2AK2, as well as 6 enriched gene-sets with FDR < 0.05. Expression quantitative trait loci analysis identified rs2242044 as a significant cis-eQTL in both the normal adipose-subcutaneous (P = 1.7 × 10<sup>−9</sup>) and adipose-visceral (P = 4.4 × 10<sup>−15</sup>) tissue. These findings may provide an important entry point to unravel genetic pleiotropy in obesity traits.</p> obesity;signaling by G protein-coupled receptor;olfactory transduction;bivariate genome-wide association study;twin study 2018-05-16
    https://frontiersin.figshare.com/articles/dataset/Table_2_Genetics_of_Obesity_Traits_A_Bivariate_Genome-Wide_Association_Analysis_docx/6275648
10.3389/fgene.2018.00179.s002