10.3389/fgene.2018.00179.s002 Yili Wu Yili Wu Haiping Duan Haiping Duan Xiaocao Tian Xiaocao Tian Chunsheng Xu Chunsheng Xu Weijing Wang Weijing Wang Wenjie Jiang Wenjie Jiang Zengchang Pang Zengchang Pang Dongfeng Zhang Dongfeng Zhang Qihua Tan Qihua Tan Table_2_Genetics of Obesity Traits: A Bivariate Genome-Wide Association Analysis.docx Frontiers 2018 obesity signaling by G protein-coupled receptor olfactory transduction bivariate genome-wide association study twin study 2018-05-16 12:10:46 Dataset https://frontiersin.figshare.com/articles/dataset/Table_2_Genetics_of_Obesity_Traits_A_Bivariate_Genome-Wide_Association_Analysis_docx/6275648 <p>Previous genome-wide association studies on anthropometric measurements have identified more than 100 related loci, but only a small portion of heritability in obesity was explained. Here we present a bivariate twin study to look for the genetic variants associated with body mass index and waist-hip ratio, and to explore the obesity-related pathways in Northern Han Chinese. Cholesky decomposition model for 242 monozygotic and 140 dizygotic twin pairs indicated a moderate genetic correlation (r = 0.53, 95%CI: 0.42–0.64) between body mass index and waist-hip ratio. Bivariate genome-wide association analysis in 139 dizygotic twin pairs identified 26 associated SNPs with p < 10<sup>−5</sup>. Further gene-based analysis found 291 nominally associated genes (P < 0.05), including F12, HCRTR1, PHOSPHO1, DOCK2, DOCK6, DGKB, GLP1R, TRHR, MMP1, GPR55, CCK, and OR2AK2, as well as 6 enriched gene-sets with FDR < 0.05. Expression quantitative trait loci analysis identified rs2242044 as a significant cis-eQTL in both the normal adipose-subcutaneous (P = 1.7 × 10<sup>−9</sup>) and adipose-visceral (P = 4.4 × 10<sup>−15</sup>) tissue. These findings may provide an important entry point to unravel genetic pleiotropy in obesity traits.</p>