TY - DATA T1 - Wide-range CRP versus high-sensitivity CRP on Roche analyzers: focus on low-grade inflammation ranges and high-sensitivity cardiac troponin T levels PY - 2018/05/16 AU - Denis Monneret AU - Fouzi Mestari AU - Shaedah Djiavoudine AU - Guillaume Bachelot AU - Maxime Cloison AU - Françoise Imbert-Bismut AU - Maguy Bernard AU - Pierre Hausfater AU - Jean-Marc Lacorte AU - Dominique Bonnefont-Rousselot UR - https://tandf.figshare.com/articles/journal_contribution/Wide-range_CRP_versus_high-sensitivity_CRP_on_Roche_analyzers_focus_on_low-grade_inflammation_ranges_and_high-sensitivity_cardiac_troponin_T_levels/6275132 DO - 10.6084/m9.figshare.6275132.v1 L4 - https://ndownloader.figshare.com/files/11471357 KW - C-reactive protein KW - inflammation KW - cardiovascular system KW - cardiovascular risk KW - troponin T N2 - Wide-range C-reactive protein (wr-CRP) has been proposed as an economical alternative to high-sensitivity C-reactive protein (hs-CRP) for the evaluation of low-grade inflammation-associated cardiovascular risk (LGI-CVR). Concomitant values of serum hs-CRP and plasma wr-CRP ≤5 mg/L, and high-sensitivity cardiac troponin T (hs-cTnT), all assayed on Roche Diagnostics analyzers over a 1.8-year period, were extracted from a hospital laboratory database. Hs-CRP and wr-CRP values were compared (Bland–Altman method; Deming’s correlation), then separately classified into low (<1 mg/L), moderate (1–3 mg/L) and high (>3 mg/L) LGI-CVR ranges for agreement test (κ), assessed before and after Deming’s regression-based adjustment of wr-CRP (Adj-wr-CRP). Wr-CRP and hs-CRP values were strongly correlated, with linearity, whether below 5 mg/L (n = 744; τ = 0.933; p < .001) or below 1 mg/L (n = 283; τ = 0.823; p < .001). Overall, wr-CRP values were lower than hs-CRP (mean bias: –0.11 ± 0.17 mg/L). Agreement was good, with 8.1% of wr-CRP values misclassified compared to hs-CRP (κ: 0.874), and weakly improved after regression-based adjustment (7.7% reclassified values; κ: 0.881). Lowering the Adj-wr-CRP cutoff of the moderate LGI-CVR subrange from 1.0 to 0.9 mg/L resulted in an almost perfect agreement (3.2% reclassified data; κ: 0.950). Hs-cTnT concentration was positively associated with hs-CRP, wr-CRP, and Adj-wr-CRP (p < .001). Within each LGI-CVR subrange, hs-cTnT medians were similar regardless of the hs-CRP, wr-CRP or Adj-wr-CRP used for risk classification. Based on hs-cTnT, this study supports the use of wr-CRP as a low-cost alternative to hs-CRP for cardiovascular risk evaluation. ER -