Phage survival after oral administration.
Karina Ramirez
Carmina Cazarez-Montoya
Hector Samuel Lopez-Moreno
Nohelia Castro-del Campo
10.1371/journal.pone.0195023.g005
https://plos.figshare.com/articles/figure/Phage_survival_after_oral_administration_/6272450
<p>Mice (n = 5 per group) were orally exposed to a single dose of 10, 6, 3 log<sub>10</sub> PFU/mL of the free or microencapsulated phage cocktails. The control group included mice treated with mineral water. (A) Faecal shedding after seven days of the administration of the free or microencapsulated phage cocktails at different doses. Results are expressed as mean phage titres ± SEM of two independent experiments. *, <i>P</i><0.02 compared to free phages. Closed triangles indicate mean phage dose plus baseline phage titres. (B) Percentage reduction in <i>E</i>. <i>coli</i> shedding in free or microencapsulated phage cocktail-treated mice on day 7 was determined relative to baseline counts found in mice before treatment. Values represent mean concentration ± SEM of two independent experiments. Numbers above bars indicate mean log<sub>10</sub> CFU/g of <i>E</i>. <i>coli</i> reduction. No significant differences were observed between groups.</p>
2018-05-15 22:27:36
stability
coli
phage proteins
characterised lytic bacteriophages
UV light intensities
food safety problem
vivo studies
pH
formulation