10.1371/journal.pone.0195023.g005 Karina Ramirez Karina Ramirez Carmina Cazarez-Montoya Carmina Cazarez-Montoya Hector Samuel Lopez-Moreno Hector Samuel Lopez-Moreno Nohelia Castro-del Campo Nohelia Castro-del Campo Phage survival after oral administration. Public Library of Science 2018 stability coli phage proteins characterised lytic bacteriophages UV light intensities food safety problem vivo studies pH formulation 2018-05-15 22:27:36 Figure https://plos.figshare.com/articles/figure/Phage_survival_after_oral_administration_/6272450 <p>Mice (n = 5 per group) were orally exposed to a single dose of 10, 6, 3 log<sub>10</sub> PFU/mL of the free or microencapsulated phage cocktails. The control group included mice treated with mineral water. (A) Faecal shedding after seven days of the administration of the free or microencapsulated phage cocktails at different doses. Results are expressed as mean phage titres ± SEM of two independent experiments. *, <i>P</i><0.02 compared to free phages. Closed triangles indicate mean phage dose plus baseline phage titres. (B) Percentage reduction in <i>E</i>. <i>coli</i> shedding in free or microencapsulated phage cocktail-treated mice on day 7 was determined relative to baseline counts found in mice before treatment. Values represent mean concentration ± SEM of two independent experiments. Numbers above bars indicate mean log<sub>10</sub> CFU/g of <i>E</i>. <i>coli</i> reduction. No significant differences were observed between groups.</p>