%0 Figure %A Wissel, Kirsten %A Brandes, Gudrun %A Pütz, Nils %A Angrisani, Gian Luigi %A Thieleke, Jan %A Lenarz, Thomas %A Durisin, Martin %D 2018 %T Ultrastructure of the SH-SY5Y cell line cultivated in absence and presence of Pt-Diss. %U https://plos.figshare.com/articles/figure/Ultrastructure_of_the_SH-SY5Y_cell_line_cultivated_in_absence_and_presence_of_Pt-Diss_/6271406 %R 10.1371/journal.pone.0196649.g007 %2 https://ndownloader.figshare.com/files/11459519 %K NIH 3 T 3 %K SH-SY 5Y cells %K SH-SY 5Y cell lines %K electrode contacts %K Pt-NP %K cell culture models %K NIH 3 T 3 cells %K TEM %K size 3 nm %K CI %K transmission electron microscopy %K Pt ions %K WST %K cochlear implants %K cell types %K cell culture model %K Platinum corrosion products %K cell death %K ICP-MS %X

After cultivation either without any Pt as reference (A) or in culture medium containing 6.0 μg/ml (B), 0.11 μg/ml (C) or 0.02 μg/ml Pt (D) SH-SY5Y were characterized by large euchromatic nucleus, abundant endoplasmic reticulum and a few synaptic granules (arrowheads). At the highest tested Pt concentration these cells were adversely affected, as proven by mitochondrial swelling (arrow in B). A smaller amount of Pt in the culture medium induced no morphological changes in comparison with the control. Size of bars: 2 μm.

%I PLOS ONE