%0 Generic
%A R., Knight
%A M., Khondoker
%A N., Magill
%A R., Stewart
%A S., Landau
%D 2018
%T Supplementary Material for: A Systematic Review and Meta-Analysis of the Effectiveness of Acetylcholinesterase Inhibitors and Memantine in Treating the Cognitive Symptoms of Dementia
%U https://karger.figshare.com/articles/dataset/Supplementary_Material_for_A_Systematic_Review_and_Meta-Analysis_of_the_Effectiveness_of_Acetylcholinesterase_Inhibitors_and_Memantine_in_Treating_the_Cognitive_Symptoms_of_Dementia/6226745
%R 10.6084/m9.figshare.6226745.v1
%2 https://ndownloader.figshare.com/files/11353817
%K Acetylcholinesterase inhibitor
%K Memantine
%K Alzheimer disease
%K Vascular dementia
%K Systematic review
%K Meta-analysis
%X Background: Acetylcholinesterase inhibitors (AChEIs) and memantine are commonly used in the management of dementia. In routine clinical practice, dementia is often monitored via the Mini-Mental State Examination (MMSE). We conducted a systematic review and meta-analysis of the effects of these drugs on MMSE scores. Summary: Eighty trials were identified. Pooled effect estimates were in favour of both AChEIs and memantine at 6 months. Meta-regression indicated that dementia subtype was a moderator of AChEI treatment effect, with the effect of treatment versus control twice as high for patients with Parkinson disease dementia/ dementia with Lewy bodies (2.11 MMSE points at 6 months) as for patients with Alzheimer disease/vascular dementia (0.91 MMSE points at 6 months). Key Messages: AChEIs demonstrate a modest effect versus control on MMSE scores which is moderated by dementia subtype. For memantine the effect is smaller.
%I Karger Publishers