%0 Generic %A R., Knight %A M., Khondoker %A N., Magill %A R., Stewart %A S., Landau %D 2018 %T Supplementary Material for: A Systematic Review and Meta-Analysis of the Effectiveness of Acetylcholinesterase Inhibitors and Memantine in Treating the Cognitive Symptoms of Dementia %U https://karger.figshare.com/articles/dataset/Supplementary_Material_for_A_Systematic_Review_and_Meta-Analysis_of_the_Effectiveness_of_Acetylcholinesterase_Inhibitors_and_Memantine_in_Treating_the_Cognitive_Symptoms_of_Dementia/6226745 %R 10.6084/m9.figshare.6226745.v1 %2 https://ndownloader.figshare.com/files/11353817 %K Acetylcholinesterase inhibitor %K Memantine %K Alzheimer disease %K Vascular dementia %K Systematic review %K Meta-analysis %X Background: Acetylcholinesterase inhibitors (AChEIs) and memantine are commonly used in the management of dementia. In routine clinical practice, dementia is often monitored via the Mini-Mental State Examination (MMSE). We conducted a systematic review and meta-analysis of the effects of these drugs on MMSE scores. Summary: Eighty trials were identified. Pooled effect estimates were in favour of both AChEIs and memantine at 6 months. Meta-regression indicated that dementia subtype was a moderator of AChEI treatment effect, with the effect of treatment versus control twice as high for patients with Parkinson disease dementia/ dementia with Lewy bodies (2.11 MMSE points at 6 months) as for patients with Alzheimer disease/vascular dementia (0.91 MMSE points at 6 months). Key Messages: AChEIs demonstrate a modest effect versus control on MMSE scores which is moderated by dementia subtype. For memantine the effect is smaller. %I Karger Publishers