TY - DATA T1 - Dataset for: CC002/Unc females are mouse models of exercise-induced paradoxical fat response PY - 2018/06/21 AU - Rachel McMullan AU - Martin Ferris AU - Tim A Bell AU - Vineet D Menachery AU - Ralph Baric AU - Kunjie Hua AU - Daniel Pomp AU - Abbie Smith-Ryan AU - Fernando Pardo Manuel de Villena UR - https://wiley.figshare.com/articles/dataset/Dataset_for_CC002_Unc_females_are_mouse_models_of_exercise-induced_paradoxical_fat_response/6220436 DO - 10.6084/m9.figshare.6220436.v1 L4 - https://ndownloader.figshare.com/files/11314529 L4 - https://ndownloader.figshare.com/files/11314532 L4 - https://ndownloader.figshare.com/files/11314535 L4 - https://ndownloader.figshare.com/files/11314538 L4 - https://ndownloader.figshare.com/files/11314541 KW - Collaborative Cross KW - body composition KW - High intensity interval training KW - genetic background KW - Physiology KW - Systems Biology N2 - Exercise results in beneficial health outcomes and protects against a variety of chronic diseases. However, U.S. exercise guidelines recommend identical exercise programs for everyone, despite individual variation in responses to these programs, including paradoxical fat gain. Experimental models of exercise-induced paradoxical outcomes may enable the dissection of underlying physiological mechanisms as well as the evaluation of potential interventions. Whereas several studies have identified individual mice exhibiting paradoxical fat gain following exercise, no systematic effort has been conducted to identify and characterize models of paradoxical response. Strains from the Collaborative Cross (CC) genetic reference population were used due to its high levels of genetic variation, its reproducible nature, and the observation that the CC is a rich source of novel disease models, to assess the impact genetic background has on exercise responses. We identified the strain CC002/Unc as an exercise-induced paradoxical fat response model in a controlled voluntary exercise study across multiple ages in female mice. We also found sex and genetic differences were consistent with this pattern in a study of forced exercise programs. These results provide a novel model for studies to determine the mechanisms behind paradoxical metabolic responses to exercise, and enable development of more rational personalized exercise recommendations based on factors such as age, sex, and genetic background. ER -