10.6084/m9.figshare.6151571.v1
Mariam Garelnabi
Mariam
Garelnabi
Robin C May
Robin C
May
Variability in innate host immune responses to cryptococcosis
SciELO journals
2018
Cryptococcus neoformans
host-pathogen interactions
innate immunity
infection
pathogenesis
macrophages
host variation
2018-04-18 02:46:46
Figure
https://scielo.figshare.com/articles/figure/Variability_in_innate_host_immune_responses_to_cryptococcosis/6151571
<div><p>Cryptococcosis is an invasive fungal disease caused by Cryptococcus neoformans and the closely related species C. gattii. The severe form of the disease, cryptococcal meningitis (CM), is rapidly fatal without treatment. Although typically a disease of immunocompromised (especially HIV-positive) individuals, there is growing awareness of cryptococcal disease amongst non-immunocompromised patients. Whilst substantial progress has been made in understanding the pathogenicity of C. neoformans in HIV patients, prospective data on cryptococcosis outside the context of HIV remains lacking. Below we review how innate immune responses vary between hosts depending on immunological status, and discuss risk factors and predictors of disease outcome in different groups.</p></div>