TY - DATA T1 - A possible dual role for Wnt in the maintenance of stem cell niches. PY - 2007/09/26 AU - Zach Klapholz-Brown AU - Graham G. Walmsley AU - Ysbrand M. Nusse AU - Roel Nusse AU - Patrick O. Brown UR - https://plos.figshare.com/articles/figure/_A_possible_dual_role_for_Wnt_in_the_maintenance_of_stem_cell_niches_/615051 DO - 10.1371/journal.pone.0000945.g003 L4 - https://ndownloader.figshare.com/files/944666 KW - dual KW - wnt N2 - We hypothesize that Wnt may promote self-renewal directly by raising nuclear ß-Catenin levels in stem cells and indirectly by activating the BMP inhibitor Gremlin 2 in nearby fibroblasts, thereby blocking target BMPs from promoting differentiation and loss of self-renewal capacity. ER -