TY - DATA T1 - IL-15-deficient mice have reduced inflationary CD8 T cell maintenance. PY - 2018/04/13 AU - Nicolas S. Baumann AU - Nicole Torti AU - Suzanne P. M. Welten AU - Isabel Barnstorf AU - Mariana Borsa AU - Katharina Pallmer AU - Jennifer D. Oduro AU - Luka Cicin-Sain AU - Koichi Ikuta AU - Burkhard Ludewig AU - Annette Oxenius UR - https://plos.figshare.com/articles/figure/IL-15-deficient_mice_have_reduced_inflationary_CD8_T_cell_maintenance_/6141398 DO - 10.1371/journal.ppat.1006993.g005 L4 - https://ndownloader.figshare.com/files/11202860 KW - CD 8 T cell response KW - CMV KW - memory CD 8 T cells KW - IL -15 Cytomegalovirus KW - effector cells KW - memory T cells KW - CD 8 T cells KW - T cell survival KW - lung tissue N2 - (A) Naïve C57BL/6 mice and IL-15-/- mice were infected i. v. with MCMVΔm157. Percentages of M38-specific CD8 T cells of total lymphocytes were longitudinally measured in the blood. (B) Total number of M38-specific CD8 T cells and (C) percentages of M38-specific CD8 T cells of total lymphocytes in lungs, spleen and LNs at 62 dpi are shown as mean + SEM of n = 8–10 mice representative from three independent experiments. (D) Viral titres of infected C57BL/6 and IL-15-/- mice are shown as mean of n = 2–4 mice representative of two independent experiments. (E) Mean fluorescence intensities of Bcl-2 on M38-specific CD8 T cells are shown as mean + SEM of n = 8–10 mice representative from three independent experiments. (F) Percentage of Ki67+ of M38-specific CD8 T cells in lungs, spleen and LNs at 62 dpi are shown as mean + SEM of n = 8–10 mice representative from three independent experiments. (A-E); **p<0.01; ****p<0.0001. Statistical analyses were performed using the non-parametric Mann-Whitney U test. ER -