TY - DATA T1 - Supplemental Material for Baschal et al., 2018 PY - 2018/06/20 AU - Erin E. Baschal AU - Elizabeth A. Terhune AU - Cambria I. Wethey AU - Robin M. Baschal AU - Kandice D. Robinson AU - Melissa T. Cuevas AU - Shreyash Pradhan AU - Brittan S. Sutphin AU - Matthew R.G. Taylor AU - Katherine Gowan AU - Chad G. Pearson AU - Lee A. Niswander AU - Kenneth L. Jones AU - Nancy H. Miller UR - https://gsajournals.figshare.com/articles/dataset/Supplemental_Material_for_Baschal_et_al_2018/6104780 DO - 10.25387/g3.6104780.v1 L4 - https://ndownloader.figshare.com/files/10998395 L4 - https://ndownloader.figshare.com/files/12124628 L4 - https://ndownloader.figshare.com/files/10998386 L4 - https://ndownloader.figshare.com/files/10998389 L4 - https://ndownloader.figshare.com/files/10998398 L4 - https://ndownloader.figshare.com/files/10998401 KW - Idiopathic scoliosis KW - exome sequencing KW - actin cytoskeleton KW - microtubules KW - cilia KW - extracellular matrix KW - Genetics N2 - Idiopathic scoliosis (IS) is a complex genetic disease of unknown etiology. We completed exome sequencing for five IS families and performed GO term enrichment analyses on the resulting variant lists. Overall, we identified enriched categories in our affected families that include stereocilia and other actin-based cellular projections, cilia and other microtubule-based cellular projections, and the extracellular matrix (ECM). Our results suggest that there are multiple paths to IS and provide a foundation for future studies of IS pathogenesis. ER -