10.25387/g3.6104780.v1 Erin E. Baschal Erin E. Baschal Elizabeth A. Terhune Elizabeth A. Terhune Cambria I. Wethey Cambria I. Wethey Robin M. Baschal Robin M. Baschal Kandice D. Robinson Kandice D. Robinson Melissa T. Cuevas Melissa T. Cuevas Shreyash Pradhan Shreyash Pradhan Brittan S. Sutphin Brittan S. Sutphin Matthew R.G. Taylor Matthew R.G. Taylor Katherine Gowan Katherine Gowan Chad G. Pearson Chad G. Pearson Lee A. Niswander Lee A. Niswander Kenneth L. Jones Kenneth L. Jones Nancy H. Miller Nancy H. Miller Supplemental Material for Baschal et al., 2018 GSA Journals 2018 Idiopathic scoliosis exome sequencing actin cytoskeleton microtubules cilia extracellular matrix Genetics 2018-06-20 20:52:29 Dataset https://gsajournals.figshare.com/articles/dataset/Supplemental_Material_for_Baschal_et_al_2018/6104780 <p>Idiopathic scoliosis (IS) is a complex genetic disease of unknown etiology. We completed exome sequencing for five IS families and performed GO term enrichment analyses on the resulting variant lists. Overall, we identified enriched categories in our affected families that include stereocilia and other actin-based cellular projections, cilia and other microtubule-based cellular projections, and the extracellular matrix (ECM). Our results suggest that there are multiple paths to IS and provide a foundation for future studies of IS pathogenesis.</p><p></p>