%0 Figure %A M. Newman, Ruchi %A Hall, Laura %A Kirmaier, Andrea %A Pozzi, Lu-Ann %A Pery, Erez %A Farzan, Michael %A P. O'Neil, Shawn %A Johnson, Welkin %D 2008 %T A TRIM5-CypA transcript of macaques is generated by alternative splicing. %U https://plos.figshare.com/articles/figure/_A_TRIM5_CypA_transcript_of_macaques_is_generated_by_alternative_splicing_/607271 %R 10.1371/journal.ppat.1000003.g003 %2 https://ndownloader.figshare.com/files/936831 %K trim5-cypa %K transcript %K macaques %K generated %X

A. Messenger RNA sequence spanning the junction between the TRIM5 exon-6 and CypA sequences. B. Predicted amino-acid sequence of rhesus TRIM5-CypA aligned with pig-tailed macaque TRIM5-CypA and owl monkey TRIMCyp. Residues that differ from rhesus TRIM5-CypA are highlighted in blue. The region encoded by exon-7 is boxed in red; as the result of alternative splicing, this sequence is present in owl monkey TRIMCyp, but is missing from old world monkey TRIM5-CypA. C. Cartoon depicting predicted protein sequences of the old world monkey TRIM5-CypA protein (top), the owl monkey TRIM-Cyp protein (middle) and wild type primate TRIM5α (bottom).

%I PLOS Pathogens