TY - DATA T1 - Supplemental Material for Attie et al., 2018 PY - 2018/07/13 AU - Mark P. Keller AU - daniel gatti AU - Kathryn L. Schueler AU - mary rabaglia AU - donnie s stapleton AU - petr semecek AU - matthew vincent AU - sadie allen AU - aimee teo broman AU - rhonda bacher AU - christina kendziorski AU - karl broman AU - brian yandell AU - gary churchill AU - alan attie UR - https://gsajournals.figshare.com/articles/dataset/Supplemental_Material_for_Attie_et_al_2018_in_review_/5977459 DO - 10.25386/genetics.5977459.v2 L4 - https://ndownloader.figshare.com/files/10725022 L4 - https://ndownloader.figshare.com/files/10725028 L4 - https://ndownloader.figshare.com/files/10725031 L4 - https://ndownloader.figshare.com/files/10725025 L4 - https://ndownloader.figshare.com/files/10725034 L4 - https://ndownloader.figshare.com/files/10725079 L4 - https://ndownloader.figshare.com/files/10725037 L4 - https://ndownloader.figshare.com/files/10725046 L4 - https://ndownloader.figshare.com/files/10725049 L4 - https://ndownloader.figshare.com/files/10725040 L4 - https://ndownloader.figshare.com/files/10725052 L4 - https://ndownloader.figshare.com/files/10725043 L4 - https://ndownloader.figshare.com/files/10725061 L4 - https://ndownloader.figshare.com/files/10725058 L4 - https://ndownloader.figshare.com/files/10725055 L4 - https://ndownloader.figshare.com/files/10725064 L4 - https://ndownloader.figshare.com/files/10725070 L4 - https://ndownloader.figshare.com/files/10725067 L4 - https://ndownloader.figshare.com/files/10725073 L4 - https://ndownloader.figshare.com/files/10725076 L4 - https://ndownloader.figshare.com/files/10824752 L4 - https://ndownloader.figshare.com/files/10824755 L4 - https://ndownloader.figshare.com/files/10824758 L4 - https://ndownloader.figshare.com/files/10824761 L4 - https://ndownloader.figshare.com/files/10824764 L4 - https://ndownloader.figshare.com/files/10824773 L4 - https://ndownloader.figshare.com/files/10824767 L4 - https://ndownloader.figshare.com/files/10824770 L4 - https://ndownloader.figshare.com/files/10824776 KW - eQTL; module-QTL; T2D; β-cell; genome-wide association (GWA) KW - Systems Biology KW - Quantitative Genetics (incl. Disease and Trait Mapping Genetics) KW - Physiology KW - Genetics KW - Gene Expression (incl. Microarray and other genome-wide approaches) N2 - Fig S1. Relationship between body weight and daily food consumption in female and male DO mice. Fig S2. Pairwise correlation among all physiological traits. Fig S3. Motif for Hnf4a is enriched in transcripts mapping to Chr 2 eQTL hotspot. Fig S4. Mediation predicts Il6st as a driver at the Chr 13 eQTL hotspot. Fig S5. Mediation predicts Pdx1 as a driver at the Chr 5 eQTL hotspot. Fig S6. Mediation predicts Fam83e as a driver at the Chr 7 eQTL hotspot.Fig S7. Mediation predicts Sat2 as a driver at the Chr 11 eQTL hotspot.Fig S8. Module color code key.Fig S9. Islet modules that were most strongly influenced by sex.Fig S10. Genome-wide LOD profile for Tcf7l2 expression in DO islets.Fig S11. Allele dependences for Tcf7l2 eQTL.Fig S12. Mediation analysis to predict candidate drivers of Tcf7l2 expression.Fig S13. SNP associations for Tcf7l2 eQTL.Supplementary Table 1. eQTL hotspots.Supplementary Table 2. Module memberships.Supplementary Table 3. GO/KEGG enrichment for all modules.Supplementary Table 4. Percent variance explained by module eigengenes (ME).Supplementary Table 5. Sex effects for module transcripts.Supplementary Table 6. Physiological QTL and their syntenic positions in human.Supplementary Table 7. Module-QTL and their syntenic positions in human.Supplementary Table 8. List of T1D and T2D associated SNPs obtained from GWAS Central.File S1. R markdown file detailing the analyses for all physiological phenotypes.File S2. R markdown file detailing the analyses for eQTL hotspots.File S3. R markdown file detailing the analyses for co-expression module eigengenes.File S4. Guide to R markdown files (Files S1 – 3) for QTL analysis.File S5. R markdown file for integration of mouse QTL with human GWAS.File S6. Data files used for GWAS integration R markdown file.File S7. Guide to R markdown file for GWAS integration. ER -