%0 Journal Article %A Li, Tian-Ren %A Maliszewski, Mary L. %A Xiao, Wen-Jing %A Tunge, Jon A. %D 2018 %T Stereospecific Decarboxylative Benzylation of Enolates: Development and Mechanistic Insight %U https://acs.figshare.com/articles/journal_contribution/Stereospecific_Decarboxylative_Benzylation_of_Enolates_Development_and_Mechanistic_Insight/5975407 %R 10.1021/acs.orglett.8b00169.s001 %2 https://ndownloader.figshare.com/files/10717090 %K reactants %K Stereospecific Decarboxylative Benzylation %K generation %K insight %K crossover %K diarylmethyl electrophiles %K variety %K benzylic alcohols %K method %K β- diaryl ketones %K stereospecific %K proceed %K intramolecular decarboxylative %K palladium-catalyzed decarboxylative %K Mechanistic Insight %K enol carbonates %K Enolate %X A palladium-catalyzed decarboxylative coupling of enol carbonates with diarylmethyl electrophiles that are derived from secondary benzylic alcohols has been developed. This method allows the generation of a variety of β-diaryl ketones through an efficient and highly stereospecific coupling. In addition, detailed mechanistic insight into the coupling suggests that the reaction is a rare example of an intramolecular decarboxylative coupling that proceeds without crossover between reactants. %I ACS Publications